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CAS No.: 83-79-4

鱼藤酮 Catalog No. CSN11866

Synonyms: Barbasco;Dactinol;Paraderil

Rotenone is a proven complex I inhibitor with IC50 value of 1.7 - 2.2 μM.

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生物活性

实验方案

技术信息

生物活性

描述Rotenone is a classical mitochondrial complex I inhibitor that blocks the electron transfer of mitochondrial respiration chain. It inhibits NADH oxidase and NADH/DB oxidoreductase with IC₅₀ values of 5.1 and 28.8 nM, respectively^[1]. Rotenone blocked the proliferation of MCF-7 and Hela cells by inhibiting the reassembly of microtubules with half inhibitory concentrations of 0.4 and 0.2 μM, respectively^[2]. In substantia nigra pars compacta neurons, 1 μM rotenone stimulated a tolbutamide-sensitive outward current (94 pA) accompanied with the accumulation of intracellular [Na⁺] and [Ca²⁺] ^[3]. Rotenone infusion (2 mg/kg/day for 2 days) in Lewis rats resulted in reduced binding of [³H]dihydrorotenone and complex I throughout the brain, while the enzymatic activities of cytochrome oxidase and succinate dehydrogenase remained unaffected. Systemic rotenone infusion (2.5 mg/kg/day) for 7 – 33 days led to progressive nigrostriatal dopaminergic degeneration in the brain. Compared to nigral cell bodies, striatal nerve terminals were affected more severely and earlier by rotenone infusion^[4].
作用机制Rotenone is a lipophilic inhibitor for complex I in mitochondrial electron transport chain that blocks the electron transfer from complex I to ubiquinone, thereby inhibiting oxidative phosphorylation and suppressing the synthesis of ATP^[5].
动物研究
剂量
Rat: 2 mg/kg - 3 mg/kg^[6] (i.p.); 3 mg/kg^[7] (s.c.) Mice: 0.65 mg/kg - 2.6 mg/kg^[8] (i.p.); 30 mg/kg, 100 mg/kg (p.o.)

给药途径
i.p., s.c., p.o.
参考文献

动物研究
剂量	Rat: 2 mg/kg - 3 mg/kg^[6] (i.p.); 3 mg/kg^[7] (s.c.) Mice: 0.65 mg/kg - 2.6 mg/kg^[8] (i.p.); 30 mg/kg, 100 mg/kg (p.o.)
给药途径	i.p., s.c., p.o.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.5354 mL
- 12.6768 mL
- 25.3537 mL
- 5 mM
- 0.5071 mL
- 2.5354 mL
- 5.0707 mL
- 10 mM
- 0.2535 mL
- 1.2677 mL
- 2.5354 mL

技术信息

CAS号

83-79-4

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C23H22O6

运输

蓝冰

分子量

394.42

别名

Barbasco;Dactinol;Paraderil;Rotenon;Rotocide;Nicouline;NSC 8505;NSC 26258;Tubatoxin;Cube root;bCube-Pulver;Ronone;HSDB 1762;Ro-KO;鱼藤酮

溶解度

DMSO	55.0 mg/mL (139.4 mM)
Water	Insoluble
Ethanol	2.0 mg/mL (5.1 mM)

动物实验配方

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